The town's ancient Basilica of St. Benedict collapsed leaving just the facade standing.
The quake, which measured 6.6 according to the U.S Geological Survey, was bigger than the one which hit on Aug. 24, killing almost 300 people. Many people have fled the region since then helping to avoid a new devastating death toll.
The latest quake was felt across much of Italy, striking at 7.40 a.m. (0640 GMT), its epicentre close to Norcia, some 100 km (60 miles) from the city of Perugia.