At the decaying Merrye House, feared by locals, the Merrye children Ralph, Virginia, and Elizabeth have lived in seclusion with the family chauffeur Bruno ever since their parents died. All three have advanced Merrye Syndrome, a genetic affliction unique to members of the family which causes them, starting in late childhood, to regress down the evolutionary ladder mentally and physically. They exhibit a playful innocence well before their years mixed with feral madness. Ralph is a sexually advanced, but mentally deficient simpleton who moves through the house via the dumb-waiter. Virginia is obsessed with spiders, and has more than once murdered visitors in a game of "spider", trapping them by rigging a window to snap shut on them before hacking them to death with butcher knives. Elizabeth is regarded by Bruno as the most responsible of the three, but is also conniving and infatuated with the concept of hate. The children hold a steadfast respect and affection for Bruno, but increasingly disregard his admonitions against their darker impulses.